Article
Rarity of oncogenic mutations in the thyrotropin receptor of autonomously functioning thyroid nodules in Japan.
The Journal of clinical endocrinology and metabolism - 1 Sept 1995
Takeshita A, Nagayama Y, Yokoyama N, Ishikawa N, Ito K, Yamashita T, Obara T, Murakami Y, Kuma K, Takamatsu J
Abstract excerpt
Constitutively activating mutations have recently been identified in the thyrotropin receptor (TSHR) of hyperfunctioning thyroid adenomas and familial hyperthyroidism. In the present study, we evaluated the frequency of constitutively activating TSHR mutations in a large series of autonomously fu...
Topics
- Base Sequence
- Humans
- Incidence
- Japan
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Oncogenes
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Receptors, Thyrotropin
- Thyroid Nodule