Article
Follicular carcinoma presenting as autonomous functioning thyroid nodule and containing an activating mutation of the TSH receptor (T620I) and a mutation of the Ki-RAS (G12C) genes.
Thyroid : official journal of the American Thyroid Association - 1 May 2006
Niepomniszcze Hugo, Suárez Horacio, Pitoia Fabián, Pignatta Analía, Danilowicz Karina, Manavela Marcos, Elsner Boris, Bruno Oscar D
Abstract excerpt
Most autonomous functioning thyroid nodules (AFTN) are benign thyroid follicular neoplasms. There are rare reports of malignant hot nodules, in which activating mutations of the TSH receptor (TSHR) were found. We report a case of follicular carcinoma presenting as an AFTN causing subclinical hyperthyroidism in a 64-year-old woman who had a 6-cm hot nodule in the left thyroid lobe. Genomic DNA was extracted from...
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