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Article

Autonomous adenomas caused by somatic mutations of the thyroid-stimulating hormone receptor in children.

Hormone research in paediatrics - 1 Jan 2014

Grob Francisca, Deladoëy Johnny, Legault Laurent, Spigelblatt Linda, Fournier Anne, Vassart Gilbert, Van Vliet Guy

Abstract excerpt

In adults, autonomous adenomas of the thyroid causing hyperthyroidism are relatively common and are most often due to somatic mutations that increase the constitutive activity of the thyroid-stimulating hormone receptor (TSHR). By contrast, autonomous adenomas in hyperthyroid children are exceptional and reports of their clinical and molecular characteristics are few. We reviewed papers describing 16 autonomous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24480816
DOI: 10.1159/000357143

Genes

TSHR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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