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Article

Does a Leu 512 Arg thyrotropin receptor mutation cause an autonomously functioning papillary carcinoma?

Thyroid : official journal of the American Thyroid Association - 1 Nov 2004

Gozu Hulya, Avsar Melike, Bircan Rifat, Sahin Serap, Ahiskanali Rengin, Gulluoglu Bahadir, Deyneli Oguzhan, Ones Tunc, Narin Yavuz, Akalin Sema, Cirakoglu Beyazit

Abstract excerpt

In the last decade, studies were first done to determine the frequency of Gsalpha and later thyrotropin receptor (TSHR) mutations in benign autonomously functioning thyroid nodules (AFTN). Different frequencies ranging from 0% to 38% for GSp mutations and from 20% to 86% for TSHR mutations were found. There were only some limited case reports related to TSHR genetic alterations in malignant AFTN. Their role in...

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Source

Identifiers

PMID: 15671779
DOI: 10.1089/thy.2004.14.975

Genes

TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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