Article

Antimicrobial prodrug activation by the staphylococcal glyoxalase GloB

2020-07-23

Abstract excerpt

<h4>ABSTRACT</h4> With the rising prevalence of multidrug-resistance, there is an urgent need to develop novel antibiotics. Many putative antibiotics demonstrate promising in vitro potency but fail in vivo due to poor drug-like qualities (e.g. serum half-life, oral absorption, solubility, toxicity). These drug-like properties can be modified through the addition of chemical protecting groups, creating “prodrugs...

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Literature Corpus work: 91ef88cf-991d-5294-9c3f-e65fd3f4aef5
DOI: 10.1101/2020.07.23.214460

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