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Vgb from<i>Staphylococcus aureus</i>Inactivates Streptogramin B Antibiotics by an Elimination Mechanism Not Hydrolysis

1 Jul 2001

Abstract excerpt

The streptogramin antibiotics were identified almost 50 years ago but have only recently found clinical use as a consequence of the increase in multidrug-resistant bacteria. Despite the fact that these antibiotics have historically not found intense clinical use, resistance to streptogramins exists. Streptogramins consist of a mixture of two components: cyclic polyunsaturated macrolactones (group A) and cyclic...

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PMID: 11467949
DOI: 10.1021/bi0106787

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