Resisting the resistance: the antimicrobial peptide DGL13K selects for small colony variants of Staphylococcus aureus that show increased resistance to its stereoisomer LGL13K, but not to DGL13K.

Abstract excerpt

About 30% of the population are nasal carriers of Staphylococcus aureus, a leading cause of bacteremia, endocarditis, osteomyelitis, and skin and soft tissue infections. Antibiotic-resistant bacteria, in particular, are an increasing problem in both hospital and community settings. In this study, we sought to determine the cellular consequences of long-term exposure of S. aureus to the antimicrobial peptide...

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