Article

The sex-specific effects of RAGE signaling and Type 2 Diabetes on mouse cortical bone mechanics, structure, and material properties

2025-01-02

Abstract excerpt

Individuals with type 2 diabetes (T2D) are prone to fracture at numerous skeletal sites despite presenting with a higher bone mineral density (BMD). The accumulation of Advanced Glycation End-products (AGEs) in the bone tissues of patients with T2D could be contributing to this paradox, of increased skeletal fragility with higher BMD. AGEs can impair bone cell homeostasis via the receptor for AGEs (RAGE). To inves...

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Literature Corpus work: 91c734f4-9598-5d01-9db0-c3e27182ecce
DOI: 10.1101/2025.01.01.631018

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