Article

Genetic and pharmacologic modulation of RAGE rescues the diabetes-mediated impairments to bone at multiple length scales

2026-04-06

Abstract excerpt

The bone matrix is precisely maintained and optimized to resist fractures. However, aging and disease deteriorate the bone matrix and increase fragility. Individuals with type 2 diabetes (T2D) have an elevated risk of bone fracture despite apparently normal bone mass. The chronic hyperglycemia in T2D promotes the formation of advanced glycation end-products (AGEs) in the bone tissue and modify the matrix mechanics...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 02d4c6be-c208-5ffb-9c57-dd3d77f3d5c2
DOI: 10.64898/2026.04.02.716153

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic and pharmacologic modulation of RAGE rescues the diabetes-mediated impairments to bone at multiple length scalesDOI 10.64898/2026.04.02.716153Read

The sex-specific effects of RAGE signaling and Type 2 Diabetes on mouse cortical bone mechanics, structure, and material propertiesSemantic proximity Read

Complications in the spine associated with type 2 diabetes: The role of advanced glycation end-productsSemantic proximity Read

Integrated Phenotypic and Transcriptomic Analyses of Osteoporosis in Type 2 Diabetic MiceSemantic proximity Read

Bone canonical Wnt signaling is downregulated in type 2 diabetes and associates with higher Advanced Glycation End-products (AGEs) content and reduced bone strengthSemantic proximity Read

Mouse models of type 1 diabetes and their use in skeletal researchSemantic proximity Read

The impact of SGLT2 inhibitors, compared with insulin, on diabetic bone disease in a mouse model of type 1 diabetes.Semantic proximity Read

Arterial Calcification in Diabetes Mellitus: Preclinical Models and Translational Implications.Semantic proximity Read

Profiling bone status indices reveals evidence of a low-turnover bone phenotype in type 2 diabetes: findings from the DiaFALL cohort.Semantic proximity Read

Upregulation of Parathyroid Hormone Receptor 1 (PTH1R) in Non-Mechanostimulated Osteocytes Under High-Glucose Conditions Promotes a Macrophage Pro-Inflammatory and Osteoclastogenic Phenotype via IL-6 Secretion.Semantic proximity Read

RAGE: therapeutic target and biomarker of the inflammatory response--the evidence mounts.Semantic proximity Read

The transcriptome and secreted factors of the intervertebral discs in STZ-HFD Type□2 diabetic male mice reveal extensive inflammationSemantic proximity Read

Gain-of-Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes.Semantic proximity Read