Article

Viral mediated knockdown of GATA6 in SMA iPSC-derived astrocytes prevents motor neuron loss and microglial activation

2021-10-12

Abstract excerpt

Spinal muscular atrophy (SMA), a pediatric genetic disorder, is characterized by the profound loss of spinal cord motor neurons and subsequent muscle atrophy and death. Although the mechanisms underlying motor neuron loss are not entirely clear, data from our work and others support the idea that glial cells contribute to disease pathology. GATA6, a transcription factor that we have previously shown to be upregula...

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Literature Corpus work: 91b6fc4e-11b7-5cbf-9bd7-150613b5b28a
DOI: 10.1101/2021.10.11.463972

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