Article
Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production.
Glia - 1 Sept 2013
McGivern Jered V, Patitucci Teresa N, Nord Joshua A, Barabas Marie-Elizabeth A, Stucky Cheryl L, Ebert Allison D
Abstract excerpt
Spinal muscular atrophy (SMA) is a genetic disorder caused by the deletion of the survival motor neuron 1 (SMN1) gene that leads to loss of motor neurons in the spinal cord. Although motor neurons are selectively lost during SMA pathology, selective replacement of SMN in motor neurons does not lead to full rescue in mouse models. Due to the ubiquitous expression of SMN, it is likely that other cell types besides...
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