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Article

Astrocytes influence the severity of spinal muscular atrophy.

Human molecular genetics - 15 Jul 2015

Rindt Hansjörg, Feng Zhihua, Mazzasette Chiara, Glascock Jacqueline J, Valdivia David, Pyles Noah, Crawford Thomas O, Swoboda Kathryn J, Patitucci Teresa N, Ebert Allison D, Sumner Charlotte J, Ko Chien-Ping, Lorson Christian L

Abstract excerpt

Systemically low levels of survival motor neuron-1 (SMN1) protein cause spinal muscular atrophy (SMA). α-Motor neurons of the spinal cord are considered particularly vulnerable in this genetic disorder and their dysfunction and loss cause progressive muscle weakness, paralysis and eventually premature death of afflicted individuals. Historically, SMA was therefore considered a motor neuron-autonomous disease....

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Source

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Identifiers

PMID: 25911676
DOI: 10.1093/hmg/ddv148
PMCID: PMC5007659

Genes

SMN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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