Article

Microglia influence neurofilament deposition in ALS iPSC-derived motor neurons

2022-01-01

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which upper and lower motor neuron loss is the primary phenotype, leading to muscle weakness and wasting, respiratory failure, and death. Although a portion of ALS cases are linked to one of over 50 unique genes, the vast majority of cases are sporadic in nature. However, the mechanisms underlying the motor neuron loss in either familial o...

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Literature Corpus work: 973abaa5-d069-5c5b-95d4-4cb932f1f997
DOI: 10.1101/2021.12.30.474573

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