Article

IL-1Ra and CCL5, but not IL-10, are promising targets for treating SMA astrocyte-driven pathology

2023-08-14

Abstract excerpt

Spinal muscular atrophy (SMA) is a pediatric genetic disorder characterized by the loss of spinal cord motor neurons. Although the mechanisms underlying motor neuron loss are not clear, current data suggest that glial cells contribute to disease pathology. We have previously found that SMA astrocytes drive microglial activation and motor neuron loss potentially through the upregulation of NFkB-mediated pro-inflamm...

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Literature Corpus work: 4f4a1746-c8c1-5711-92b2-d2da9f6710b6
DOI: 10.1101/2023.08.10.552842

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