Article

An integrative computational framework for personalized detection of tumor epitopes in melanoma immunotherapy

2016-08-22

Abstract excerpt

In aggressive solid tumors like melanoma, a strategy for therapy personalization can be achieved by combining high-throughput data on the patient’s specific tumor mutation and expression profiles. A remarkable case is dendritic cell-based immunotherapy, where tumor epitopes identified from the patient’s specific mutation profiles are loaded on patient-derived mature dendritic cells to stimulate cytotoxic T cell me...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 916ed48b-753f-535f-891c-19fba17c18b4
DOI: 10.7287/peerj.preprints.2385v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An integrative computational framework for personalized detection of tumor epitopes in melanoma immunotherapyDOI 10.7287/peerj.preprints.2385v1Read

Bioinformatics for Cancer Immunotherapy.Semantic proximity Read

Bioinformatics for cancer immunology and immunotherapySemantic proximity Read

Neo-intline: integrated pipeline enables neoantigen design through the in-silico presentation of T-cell epitopeSemantic proximity Read

Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma.Semantic proximity Read

A Platform for Designing Genome-Based Personalized Immunotherapy or Vaccine against Cancer.Semantic proximity Read

Proteogenomic Analysis Unveils the HLA Class I-Presented Immunopeptidome in Melanoma and EGFR-Mutant Lung Adenocarcinoma.Semantic proximity Read

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells.Semantic proximity Read

Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival.Semantic proximity Read

Exome Sequencing to Predict Neoantigens in Melanoma.Semantic proximity Read

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma.Semantic proximity Read

Targeting the tumor mutanome for personalized vaccination therapySemantic proximity Read

T-Cell Epitope Discovery for Therapeutic Cancer Vaccines.Semantic proximity Read