Article
Exome Sequencing to Predict Neoantigens in Melanoma.
Cancer immunology research - 1 Sept 2015
Pritchard Antonia L, Burel Julie G, Neller Michelle A, Hayward Nicholas K, Lopez J Alejandro, Fatho Martina, Lennerz Volker, Wölfel Thomas, Schmidt Christopher W
Abstract excerpt
The ability to use circulating peripheral blood cells and matched tumor sequencing data as a basis for neoantigen prediction has exciting possibilities for application in the personalized treatment of cancer patients. We have used a high-throughput screening approach, combining whole-exome sequence data, mRNA microarrays, and publicly available epitope prediction algorithm output to identify mutated proteins...
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