Article

STIL overexpression shortens lifespan and reduces tumor formation in mice

2023-12-05

Abstract excerpt

Centrosomes are the major microtubule organizing centers of animal cells. Supernumerary centrosomes are a common feature of human tumors and associated with karyotype abnormalities and aggressive disease, but whether they are cause or consequence of cancer remains controversial. Here, we analyzed the consequences of centrosome amplification by generating transgenic mice in which centrosome numbers can be increased...

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Literature Corpus work: 9167dae6-1df3-5b44-a990-57de514ea8ad
DOI: 10.1101/2023.12.04.569842

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