Article
STIL microcephaly mutations interfere with APC/C-mediated degradation and cause centriole amplification.
Current biology : CB - 17 Feb 2014
Arquint Christian, Nigg Erich A
Abstract excerpt
BACKGROUND: STIL is a centriole duplication factor that localizes to the procentriolar cartwheel region, and mutations in STIL are associated with autosomal recessive primary microcephaly (MCPH). Excess STIL triggers centriole amplification, raising the question of how STIL levels are regulated. RESULTS: Using fluorescence time-lapse imaging, we identified a two-step process that culminates in the elimination of...
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