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Article

ALDH marks leukemia stem cell

12 Apr 2012

Abstract excerpt

In this issue of Blood,Gerber et al use aldehyde dehydrogenase (ALDH) activity to further subdivide the CD34(+)CD38(-) compartment in the bone marrow of acute myeloid leukemia (AML) patients. They identify a unique population with intermediate ALDH activity (ALDH(int)) that contains leukemia stem cells (LSCs). Moreover, persistence of this population after therapy is a marker of clinically significant minimal...

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Identifiers

PMID: 22500050
DOI: 10.1182/blood-2012-02-406751

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