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Article

Early response evaluation by single cell signaling profiling in acute myeloid leukemia

7 Jan 2023

Abstract excerpt

Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a cohort of 32 acute myeloid leukemia (AML) patients, using 36-dimensional mass cytometry. Through supervised and unsupervised machine learning approaches, we find that reduction of...

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PMID: 36611026
DOI: 10.1038/s41467-022-35624-4

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