Article
Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder.
Cell - 5 Feb 2026
Ghoochani Ali, Heiby Julia C, Rawat Eshaan S, Medoh Uche N, Di Fraia Domenico, Dong Wentao, Gastou Marc, Rastogi Mohit, Hernandez Vincent, Nyame Kwamina, Laqtom Nouf N, Durso William, Valkova Christina, Isakova Alina, Kaether Christoph, Wernig Marius, Gomez-Ospina Natalia, Franke Christian, Ori Alessandro, Abu-Remaileh Monther
Abstract excerpt
Mutations in lysosomal genes cause neurodegeneration and neuronopathic lysosomal storage disorders (LSDs). Despite their essential role in brain homeostasis, the cell-type-specific composition and function of lysosomes remain poorly understood. Here, we report a quantitative protein atlas of lysosomes from mouse neurons, astrocytes, oligodendrocytes, and microglia. We identify dozens of proteins not previously...
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