Article

Genetic deconvolution of embryonic and maternal cell-free DNA in spent culture medium of human preimplantation embryos through deep learning

2025-01-23

Abstract excerpt

Noninvasive preimplantation genetic testing for aneuploidy based on embryonic cell-free DNA (cfDNA) released in spent embryo culture media (SECM) has brought hope in selecting embryos that are most likely to implant and grow into healthy babies during assisted reproduction. However, maternal DNA contamination in SECM significantly hampers the reliability of embryonic chromosome ploidy profiles, leading to false ne...

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Literature Corpus work: 91424956-3998-54d2-a9ab-e648f9a601ff
DOI: 10.1101/2025.01.20.633979

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