Article
Determination of fetal DNA fraction from the plasma of pregnant women using sequence read counts.
Prenatal diagnosis - 1 Aug 2015
Kim Sung K, Hannum Gregory, Geis Jennifer, Tynan John, Hogg Grant, Zhao Chen, Jensen Taylor J, Mazloom Amin R, Oeth Paul, Ehrich Mathias, van den Boom Dirk, Deciu Cosmin
Abstract excerpt
OBJECTIVE: This study introduces a novel method, referred to as SeqFF, for estimating the fetal DNA fraction in the plasma of pregnant women and to infer the underlying mechanism that allows for such statistical modeling. METHODS: Autosomal regional read counts from whole-genome massively parallel single-end sequencing of circulating cell-free DNA (ccfDNA) from the plasma of 25 312 pregnant women were used to...
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