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DNA methylome reveals cellular origin of cell-free DNA in spent medium of human preimplantation embryos

14 Jun 2021

Abstract excerpt

The discovery of embryonic cell-free DNA (cfDNA) in spent embryo culture media (SECM) has brought hope for noninvasive preimplantation genetic testing. However, the cellular origins of SECM cfDNA are not sufficiently understood, and methods for determining maternal DNA contamination are limited. Here, we performed whole-genome DNA methylation sequencing for SECM cfDNA. Our results demonstrated that SECM cfDNA was...

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PMID: 34128477
DOI: 10.1172/jci146051

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