Article

Coverage profile correction of shallow-depth circulating cell-free DNA sequencing via multi-distance learning

2019-08-20

Abstract excerpt

Shallow-depth whole-genome sequencing (WGS) of circulating cell-free DNA (ccfDNA) is a popular approach for non-invasive genomic screening assays, including liquid biopsy for early detection of invasive tumors as well as non-invasive prenatal screening (NIPS) for common fetal trisomies. In contrast to nuclear DNA WGS, ccfDNA WGS exhibits extensive inter- and intra-sample coverage variability that is not fully expl...

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Literature Corpus work: c367bad9-50ac-5164-8209-6bfa6caca3cf
DOI: 10.1101/737148

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