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Article

Valosin-containing Protein is Cargo in Amyloid Precursor Protein Extracellular Vesicles

2025-01-22

Abstract excerpt

<h4>ABSTRACT</h4> The Amyloid Precursor Protein (APP), a genetic cause of Alzheimer’s disease (AD), is a type-I transmembrane protein that is metabolized by proteolysis in the endolysomal system. APP and its metabolites are secreted by cells in extracellular vesicles (EVs). To study the function of APP-containing EVs, we isolated App-EVs from rat primary neuronal conditioned media and proteomic analysis identifie...

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Identifiers and source

Literature Corpus work
913938fa-ab0b-51b6-9d24-0279ddab571d
DOI
10.1101/2025.01.20.633888
Open publication

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Valosin-containing Protein is Cargo in Amyloid Precursor Protein Extracellular VesiclesDOI 10.1101/2025.01.20.633888
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