Parkinson’s associated protein DJ-1 regulates intercellular communication via extracellular vesicles in oxidative stress.

Abstract excerpt

<title>Abstract</title> <p>Mutations in DJ-1 cause autosomal recessive Parkinson’s disease. Several functions have been attributed to DJ-1, including a key role in the protection from oxidative stress, however how this protein contributes to PD pathogenesis is still unclear. Recently, DJ-1 has been identified at higher concentration in extracellular vesicles (EV) from biological fluids of PD patients, providing a...

Topics

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• Autophagy in Disease and Therapy
• Dynamins
• Extracellular vesicles in disease
• Fluorescent Antibody Technique
• GTP Phosphohydrolases
• Microscopy, Confocal
• Parkinson's Disease Mechanisms and Treatments
• RNA regulation and disease

Identifiers and source

Literature Corpus work

be76b20e-5359-5c82-8a1f-40e5ea7d2b8b

DOI

10.21203/rs.3.rs-5669239/v1