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Article

A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2

2020-11-17

Abstract excerpt

Proteases catalyse irreversible posttranslational modifications that often alter a biological function of the substrate. The protease dipeptidyl peptidase 4 (DPP4) is a pharmacological target in type 2 diabetes therapy primarily because it inactivates glucagon-like protein-1. DPP4 also has roles in steatosis, insulin resistance, cancers and inflammatory and fibrotic diseases. In addition, DPP4 binds to the spike p...

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Identifiers and source

Literature Corpus work
910e5167-5a7c-52f6-96a9-0fdbd473e6d8
DOI
10.20944/preprints202009.0390.v2
Open publication

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A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2DOI 10.20944/preprints202009.0390.v2
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