Article

BRET-based self-cleaving biosensors for SARS-CoV-2 3CLpro Inhibitor Discovery

2021-07-28

Abstract excerpt

The 3C-like protease (3CLpro) of SARS-CoV-2 is an attractive drug target for developing antivirals against SARS-CoV-2. A few small molecule inhibitors of 3CLpro are in clinical trials for COVID-19 treatments and more inhibitors are being developed. One limiting factor for 3CLpro inhibitors development is that the cellular activities of such inhibitors have to be evaluated in a Biosafety Level 3 (BSL-3) or BSL-4 la...

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Literature Corpus work: 0c7cebab-7c08-51f4-89e9-61a75c6e9a71
DOI: 10.1101/2021.07.28.454072

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