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Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

9 Jul 2013

Abstract excerpt

The spike glycoprotein (S) of recently identified Middle East respiratory syndrome coronavirus (MERS-CoV) targets the cellular receptor, dipeptidyl peptidase 4 (DPP4). Sequence comparison and modeling analysis have revealed a putative receptor-binding domain (RBD) on the viral spike, which mediates this interaction. We report the 3.0 Å-resolution crystal structure of MERS-CoV RBD bound to the extracellular domain...

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PMID: 23835475
DOI: 10.1038/cr.2013.92

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