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Label-Free Tracking of Subcortical White Matter Degradation In Vivo Using Third Harmonic Generation Microscopy in a Mouse Model of Multiple Sclerosis

2025-08-02

Abstract excerpt

Early detection and characterization of myelin degradation in the white matter (WM) is important for understanding neurodegenerative diseases such as multiple sclerosis (MS) and dementia. Here, we demonstrate a label-free in vivo imaging technique using third harmonic generation (THG) microscopy at 1320-nm excitation, which enables visualization of subcellular myelin structural changes deep in the mouse brain. By...

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Literature Corpus work: 90fa2365-f1a7-564e-aa31-10e42d27c3db
DOI: 10.1101/2025.07.31.667796

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