Article

Dynamic imaging of myelin pathology in physiologically preserved human brain tissue using third harmonic generation microscopy

2024-09-12

Abstract excerpt

Myelin pathology is known to play a central role in disorders such as multiple sclerosis (MS) among others. Despite this, the pathological mechanisms underlying these conditions are often difficult to unravel. Conventional techniques like immunohistochemistry or dye-based approaches, do not provide a temporal characterization of the pathophysiological aberrations responsible for myelin changes in human specimens....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c3eee3bf-40dd-5b36-8cfd-ba18703a58d3
DOI: 10.1101/2024.09.06.611764

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dynamic imaging of myelin pathology in physiologically preserved human brain tissue using third harmonic generation microscopyDOI 10.1101/2024.09.06.611764Read

Label-Free Tracking of Subcortical White Matter Degradation In Vivo Using Third Harmonic Generation Microscopy in a Mouse Model of Multiple SclerosisSemantic proximity Read

Focal and subtle myelin damage in multiple sclerosis-derived post-mortem human brain slice culturesSemantic proximity Read

Human Myelin Spheres for In Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease ModelingSemantic proximity Read

Development of a human pluripotent stem cell-derived in vitro model of myelinationSemantic proximity Read

Oligodendrocyte maturation alters the cell death mechanisms that cause demyelinationSemantic proximity Read

Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesisSemantic proximity Read

Individual Astrocyte Morphology in the Collagenous Lamina Cribrosa Revealed by Multicolor DiOlistic LabelingSemantic proximity Read

Multiple sclerosis iPSC-derived oligodendroglia conserve their intrinsic properties to functionally interact with axons and glia in vivoSemantic proximity Read

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelinationSemantic proximity Read

Imaging unlabeled axons in the mouse retina by second harmonic generationSemantic proximity Read

Development of passive CLARITY and immunofluorescent labelling of multiple proteins in human cerebellum: understanding mechanisms of neurodegeneration in mitochondrial disease.Semantic proximity Read

Large-scale segmentation model facilitates intraoperative histopathology by third harmonic generation microscopySemantic proximity Read