Article

Vascular dementia increases levels of methylenetetrahydrofolate reductase and cystathionine β-synthase in female patients and changes gene expression of acetylcholine and glutamate clathrin-sculpted transport vesicles

2025-11-25

Abstract excerpt

Deficiencies in one-carbon (1C) metabolism are linked to the onset of vascular dementia (VaD). Our previous work using mouse models has demonstrated that reduced dietary intake of folic acid or genetic deficiencies in 1C metabolism result in worse outcomes using a model of VaD. This study aims to provide a detailed molecular portrait of 1C metabolism within the context of VaD, shedding light on potential molecular...

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Literature Corpus work: 90f801f6-bdb0-5e60-8eb9-3ff192cac14d
DOI: 10.1101/2025.11.21.689865

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Vascular dementia increases levels of methylenetetrahydrofolate reductase and cystathionine β-synthase in female patients and changes gene expression of acetylcholine and glutamate clathrin-sculpted transport vesiclesDOI 10.1101/2025.11.21.689865Read

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