Article

Brain B Vitamin Status and One-Carbon Metabolism Gene Polymorphisms are Associated with Cognitive Impairment in Alzheimer’s and Parkinson’s Disease

2026-04-24

Abstract excerpt

<h4>Introduction</h4> Disturbances in one-carbon metabolism and homocysteine (Hcy) regulation have been implicated in Alzheimer’s disease (AD) and Parkinson’s disease (PD), yet direct evidence from human brain tissue and the contribution of genetic variation remain limited. We investigated whether B-vitamin-related metabolic deficits and polymorphisms in one-carbon metabolism pathways contribute to cognitive impa...

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Literature Corpus work: 55997d53-d6bb-5789-aca8-b54a76316ee0
DOI: 10.64898/2026.04.22.719490

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