Article
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2005
Kohlmeier Martin, da Costa Kerry-Ann, Fischer Leslie M, Zeisel Steven H
Abstract excerpt
Choline is a required nutrient, and some humans deplete quickly when fed a low-choline diet, whereas others do not. Endogenous choline synthesis can spare some of the dietary requirement and requires one-carbon groups derived from folate metabolism. We examined whether major genetic variants of folate metabolism modify susceptibility of humans to choline deficiency. Fifty-four adult men and women were fed diets...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.