Absence of nigral degeneration in aged parkin/DJ‐1/PINK1 triple knockout mice

Abstract excerpt

Recessively inherited loss-of-function mutations in the parkin, DJ-1, or PINK1 gene are linked to familial cases of early-onset Parkinson's diseases (PD), and heterozygous mutations are associated with increased incidence of late-onset PD. We previously reported that single knockout mice lacking Parkin, DJ-1, or PINK1 exhibited no nigral degeneration, even though evoked dopamine release from nigrostriatal...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Nerve injury and regeneration
• Share to Nuclear Receptors and Signaling
• Share to Parkinson's Disease Mechanisms and Treatments