Macrophages protect against sensory axon degeneration in diabetic neuropathy

Abstract excerpt

<title>Abstract</title> <p>Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, causing sensory loss and debilitating neuropathic pain1,2. Although the onset and progression of DPN have been linked with dyslipidemia and hyperglycemia3, the contribution of inflammation in the pathogenesis of DPN has not been investigated. Here, we use a High Fat High Fructose Diet (HFHFD) to model DPN and its...

Topics

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• Adipose Tissue and Metabolism
• Diabetes Mellitus, Type 2
• Diabetic Neuropathies
• Dyslipidemias
• Hyperglycemia
• Nerve injury and regeneration
• Neuroinflammation and Neurodegeneration Mechanisms
• Pain Mechanisms and Treatments

Identifiers and source

Literature Corpus work

90dda881-5c65-545a-9806-6ab6303720a0

DOI

10.21203/rs.3.rs-3922035/v1