Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathy

Abstract excerpt

<h4>ABSTRACT</h4> Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes mellitus that is caused by metabolic toxicity to peripheral axons. We aimed to gain deep mechanistic insight into the disease process using bulk and spatial RNA sequencing on tibial and sural nerves recovered from lower leg amputations in a mostly diabetic population. First, our approach comparing mixed sensory and moto...

Topics

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• Adipose Tissue and Metabolism
• Algorithms
• Barrier Structure and Function Studies
• Hereditary Sensory and Motor Neuropathy
• Neuroinflammation and Neurodegeneration Mechanisms
• Pain Mechanisms and Treatments
• Peripheral Nervous System Diseases
• Phenotype

Identifiers and source

Literature Corpus work

716f9605-6ccc-5822-80f9-0024e76f2834

DOI

10.1101/2024.06.15.599167