Article

Epidermal Langerhans Cells Drive Painful Diabetic Neuropathy in a Sex-dependent Manner

2025-02-04

Abstract excerpt

<h4>ABSTRACT</h4> The interaction between non-neuronal cells and nerve endings in the epidermis significantly influences the development of various diseases, including Painful Diabetic Neuropathy (PDN). PDN is a common and challenging complication of diabetes, characterized by changes in skin innervation accompanied by neuropathic pain. While there is growing evidence that epidermal non-neuronal cells, such as re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a1eae3a-de56-5351-acc4-2b8c857bb5b2
DOI: 10.1101/2025.01.30.635734

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epidermal Langerhans Cells Drive Painful Diabetic Neuropathy in a Sex-dependent MannerDOI 10.1101/2025.01.30.635734Read

Alteration of nociceptive Schwann cells in a mouse model of high-fat diet induced diabetic peripheral neuropathySemantic proximity Read

Macrophages protect against sensory axon degeneration in diabetic neuropathySemantic proximity Read

Macrophages protect against sensory axon degeneration in diabetic neuropathySemantic proximity Read

Keratinocyte-Derived Exosomes in Painful Diabetic NeuropathySemantic proximity Read

Intravenous streptozotocin induces variants in painful diabetic peripheral neuropathy in female miceSemantic proximity Read

A subpopulation of peripheral sensory neurons expressing the Mas-related G Protein-Coupled Receptor d (Mrgprd) generates pain hypersensitivity in painful diabetic neuropathySemantic proximity Read

Transcriptomic analysis of human sensory neurons in painful diabetic neuropathy reveals inflammation and neuronal lossSemantic proximity Read

Transcriptomic Analysis of Human Sensory Neurons in Painful Diabetic Neuropathy Reveals Inflammation and Neuronal LossSemantic proximity Read

Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathySemantic proximity Read

Abnormal Intraepidermal Nerve Fiber Density in Disease: A Scoping ReviewSemantic proximity Read

The Development of Mechanical Allodynia in Diabetic Rats Revealed by Single-Cell RNA-SeqSemantic proximity Read

Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticitySemantic proximity Read