Article

Transcriptomic Analysis of Human Sensory Neurons in Painful Diabetic Neuropathy Reveals Inflammation and Neuronal Loss

2021-07-25

Abstract excerpt

Pathological sensations caused by peripheral painful neuropathy occurring in Type 2 diabetes mellitus (T2DM) are often described as ‘sharp’ and ‘burning’ and are commonly spontaneous in origin. Proposed etiologies implicate dysfunction of nociceptive sensory neurons in dorsal root ganglia (DRG) induced by generation of reactive oxygen species, microvascular defects, and ongoing axonal degeneration and regeneration...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f8a6427-4321-5f6e-9b6f-d586b001e958
DOI: 10.1101/2021.07.23.453576

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic Analysis of Human Sensory Neurons in Painful Diabetic Neuropathy Reveals Inflammation and Neuronal LossDOI 10.1101/2021.07.23.453576Read

Transcriptomic analysis of human sensory neurons in painful diabetic neuropathy reveals inflammation and neuronal lossSemantic proximity Read

A genome-wide screen reveals microRNAs in peripheral sensory neurons driving painful diabetic neuropathySemantic proximity Read

Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathySemantic proximity Read

Integrative Multiomic Analyses of Diabetic Neuropathic Pain in Dorsal Root Ganglia: Proteomics, Phospho-proteomics, and MetabolomicsSemantic proximity Read

Progressive neurodegeneration in human dorsal root ganglion from diabetes to painful neuropathySemantic proximity Read

Macrophages protect against sensory axon degeneration in diabetic neuropathySemantic proximity Read

The Development of Mechanical Allodynia in Diabetic Rats Revealed by Single-Cell RNA-SeqSemantic proximity Read

Macrophages protect against sensory axon degeneration in diabetic neuropathySemantic proximity Read

Transcriptome profiling of dorsal root ganglia in a rat model of complex regional pain syndrome type-I reveals potential mechanisms involved in painSemantic proximity Read

High-Resolution Whole-Genome DNA Methylation Revealed Unique Signatures of Painful Diabetic NeuropathySemantic proximity Read

ALOX15-Mediated Neuron Ferroptosis Was Involved in Diabetic Peripheral Neuropathic PainSemantic proximity Read