Article

Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells

2021-02-25

Abstract excerpt

Rett Syndrome is a neurodevelopmental disorder in girls that is caused by heterozygous inactivation of the chromatin remodeler gene MECP2 . Rett Syndrome may therefore be treated by reactivation of the wild type copy of MECP2 from the inactive X chromosome. Most studies that model Mecp2 reactivation have used mouse fibroblasts rather than neural cells, which would be critical for phenotypic reversal, and rely o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 90d89f09-3c2c-57a2-b900-0c49e17ea8d3
DOI: 10.1101/2021.02.25.432827

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cellsDOI 10.1101/2021.02.25.432827Read

A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance.Semantic proximity Read

Pharmacological reactivation of inactive X-linked Mecp2 in cerebral cortical neurons of living mice.Semantic proximity Read

X-chromosome inactivation patterns are unbalanced and affect the phenotypic outcome in a mouse model of rett syndrome.Semantic proximity Read

Multiplex Epigenome Editing of <i>MECP2</i> to Rescue Rett Syndrome NeuronsSemantic proximity Read

Selective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome.Semantic proximity Read

Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function.Semantic proximity Read

Transcriptional regulation in pluripotent stem cells by methyl CpG-binding protein 2 (MeCP2).Semantic proximity Read

Cell-Type-Specific Gene Inactivation and In Situ Restoration via Recombinase-Based Flipping of Targeted Genomic Region.Semantic proximity Read

Human X chromosome inactivation and reactivation: implications for cell reprogramming and disease.Semantic proximity Read

State-of-the-art therapies for Rett syndrome.Semantic proximity Read

Role of epigenetics in Rett syndrome.Semantic proximity Read

Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons.Semantic proximity Read