Article
STAT5B mutations in myeloid neoplasms differ by disease subtypes but characterize a subset of chronic myeloid neoplasms with eosinophilia and/or basophilia.
Haematologica - 1 Jun 2024
Yin C Cameron, Tam Wayne, Walker Serena M, Kaur Amandeep, Ouseph Madhu M, Xie Wei, K Weinberg Olga, Li Peng, Zuo Zhuang, Routbort Mark J, Chen Simon, Medeiros L Jeffrey, George Tracy I, Orazi Attilio, Arber Daniel A, Bagg Adam, Hasserjian Robert P, Wang Sa A
Abstract excerpt
STAT5B has been reported as a recurrent mutation in myeloid neoplasms with eosinophilia, but its overall frequency and importance across a spectrum of myeloid neoplasms are largely unknown. We conducted a multicenter study on a series of 82 myeloid neoplasms with STAT5B mutations detected by next-generation sequencing. The estimated frequency of STAT5B mutations in myeloid neoplasms was low, <0.5%, but mutations...
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