Article

Uveal and cutaneous melanoma share a common mutation with distinct prognostic implications: A bioinformatic study

2026-08-11

Abstract excerpt

<h4>What was known before:</h4> Uveal melanoma (UM) and cutaneous melanoma (CM) arise from a common melanocytic lineage but exhibit distinct genetic landscapes, biological behavior, and clinical outcomes. Pigmentation-related genes, including IRF4 and HERC2, have been implicated in melanoma susceptibility and prognosis; however, the extent of shared genetic variants between UM and CM has remained unclear. Previou...

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Literature Corpus work: 90c6ba78-1437-5138-b3fb-01334389d4d6
DOI: 10.64898/2026.08.07.26359988

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