Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic markers of pigmentation are novel risk loci for uveal melanoma.

Scientific reports - 8 Aug 2016

Ferguson Robert, Vogelsang Matjaz, Ucisik-Akkaya Esma, Rai Karan, Pilarski Robert, Martinez Carlos N, Rendleman Justin, Kazlow Esther, Nagdimov Khagay, Osman Iman, Klein Robert J, Davidorf Frederick H, Cebulla Colleen M, Abdel-Rahman Mohamed H, Kirchhoff Tomas

Abstract excerpt

While the role of genetic risk factors in the etiology of uveal melanoma (UM) has been strongly suggested, the genetic susceptibility to UM is currently vastly unexplored. Due to shared epidemiological risk factors between cutaneous melanoma (CM) and UM, in this study we have selected 28 SNPs identified as risk variants in previous genome-wide association studies on CM or CM-related host phenotypes (such as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Genome-Wide Association Study

Share to Melanoma

Share to Pigmentation

Share to Risk Factors

Share to Uveal Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 27499155
DOI: 10.1038/srep31191
PMCID: PMC4976361

Genes

HERC2
OCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic markers of pigmentation are novel risk loci for uveal melanoma.PMID 27499155Read ↗

Genome-wide association study identifies novel loci predisposing to cutaneous melanoma.Semantic proximity Read ↗

Uveal and cutaneous melanoma share a common mutation with distinct prognostic implications: A bioinformatic studySemantic proximity Read ↗

Genetics of pigmentation and melanoma predisposition.Semantic proximity Read ↗

Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma.Semantic proximity Read ↗

Survival in Patients with Uveal Melanoma Is Linked to Genetic Variation at HERC2 Single Nucleotide Polymorphism rs12913832.Semantic proximity Read ↗

Pigmentation-related genes and their implication in malignant melanoma susceptibility.Semantic proximity Read ↗

Worldwide Incidence of Ocular Melanoma and Correlation With Pigmentation-Related Risk FactorsSemantic proximity Read ↗

Increased risk of developing cutaneous malignant melanoma is associated with variation in pigmentation genes and VDR, and may involve epistatic effects.Semantic proximity Read ↗

Different Pigmentation Risk Loci for High-Risk Monosomy 3 and Low-Risk Disomy 3 Uveal MelanomasSemantic proximity Read ↗

Single-nucleotide polymorphisms in pigment genes and nonmelanoma skin cancer predisposition: a systematic review.Semantic proximity Read ↗

Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.Semantic proximity Read ↗

Genetic analysis of three important genes in pigmentation and melanoma susceptibility: CDKN2A, MC1R and HERC2/OCA2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.