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Different Pigmentation Risk Loci for High-Risk Monosomy 3 and Low-Risk Disomy 3 Uveal Melanomas

19 Aug 2021

Abstract excerpt

BACKGROUND: Uveal melanoma (UM), a rare malignant tumor of the eye, is predominantly observed in populations of European ancestry. UMs carrying a monosomy 3 (M3) frequently relapse mainly in the liver, whereas UMs with disomy 3 (D3) are associated with more favorable outcome. Here, we explored the UM genetic predisposition factors in a large genome-wide association study (GWAS) of 1142 European UM patients and...

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Share to Cutaneous Melanoma Detection and Management
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34424336
DOI: 10.1093/jnci/djab167

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