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Article

GWAS meta-analysis provides new insights into uveal melanoma risk.

British journal of cancer - 1 Sept 2026

D'Mellow Matthew, Wang Huanwei, Palmer Jane M, Hemminki Kari, Cebulla Colleen M, Beasley Aaron B, Bechrakis Nikolaos E, Pritchard Antonia L, Wadt Karin W, Johansson Peter A, Mobuchon Lenha, Barlow Samantha, Brooks Kelly, Beckman Timothy, Olsen Catherine M, Warrier Sunil K, Byrne Lindsey, Kalirai Helen, Mustard Colette, Ingold Nathan, Försti Asta, Isaacs Timothy, Jayasinghe G J M Shanika R, Glasson William J, Williamson Gayle, McGrath Lindsay A, Le Ngoc-Quynh, Chadha Vikas, Gray Elin S, Brown Kevin M, Cauchi Paul, Thomsen Hauke, Connolly Julie, MacGregor Stuart, Whiteman David C, Kiilgaard Jens F, Stern Marc-Henri, Coupland Sarah E, Abdel-Rahman Mohamed H, Zeschnigk Michael, Hayward Nick, Law Matthew H

Abstract excerpt

OBJECTIVE: The aim of this research is to identify germline genetic variants that predispose to uveal melanoma (UM) using data from nine studies involving 5839 individuals with UM (3853 novel) and 349,863 healthy controls. METHODS: Five novel UM genome-wide association studies (GWAS) were performed and included for meta-analysis with four previously published UM GWAS. A fixed-effects inverse-variance weighted...

Read the complete abstract on PubMed

Topics

Humans
Uveal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Melanoma

Genome-Wide Association Study

Uveal Melanoma

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Case-Control Studies

Linkage Disequilibrium

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 42303830
DOI: 10.1038/s41416-026-03499-7
PMCID: PMC13534482

Genes

MOB3B
MTSS1
RBAK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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