Article
An Optimized NGS Workflow Defines Genetically Based Prognostic Categories for Patients with Uveal Melanoma.
Biomolecules - 18 Jan 2025
Massimino Michele, Tirrò Elena, Stella Stefania, Tomarchio Cristina, Di Bella Sebastiano, Vitale Silvia Rita, Conti Chiara, Puglisi Marialuisa, Di Crescenzo Rosa Maria, Varricchio Silvia, Merolla Francesco, Broggi Giuseppe, Martorana Federica, Turdo Alice, Gaggianesi Miriam, Manzella Livia, Russo Andrea, Stassi Giorgio, Caltabiano Rosario, Staibano Stefania, Vigneri Paolo
Abstract excerpt
BACKGROUND: Despite advances in uveal melanoma (UM) diagnosis and treatment, about 50% of patients develop distant metastases, thereby displaying poor overall survival. Molecular profiling has identified several genetic alterations that can stratify patients with UM into different risk categories. However, these genetic alterations are currently dispersed over multiple studies and several methodologies,...
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