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Article

Unveiling the genetic landscape of hereditary melanoma: From susceptibility to surveillance.

Cancer treatment and research communications - 1 Jan 2024

Zheng Chenming, Sarin Kavita Y

Abstract excerpt

The multifactorial etiology underlying melanoma development involves an array of genetic, phenotypic, and environmental factors. Genetic predisposition for melanoma is further influenced by the complex interplay between high-, medium-, and low-penetrance genes, each contributing to varying degrees of susceptibility. Within this network, high-penetrance genes, including CDKN2A, CDK4, BAP1, and POT1, are linked to...

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Source

Identifiers

PMID: 39137473
DOI: 10.1016/j.ctarc.2024.100837

Genes

BAP1
CDK4
CDKN2A
MC1R
MITF
POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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