Article

Chaperoning the chaperones: Proteomic analysis of the SMN complex reveals conserved and etiologic connections to the proteostasis network

2024-05-16

Abstract excerpt

Molecular chaperones and co-chaperones are highly conserved cellular components that perform variety of duties related to the proper three-dimensional folding of the proteome. The web of factors that carries out this essential task is called the proteostasis network (PN). Ribonucleoproteins (RNPs) represent an underexplored area in terms of the connections they make with the PN. The Survival Motor Neuron (SMN) com...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94445623-0115-55d1-8d7b-ebe4367a6918
DOI: 10.1101/2024.05.15.594402

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chaperoning the chaperones: Proteomic analysis of the SMN complex reveals conserved and etiologic connections to the proteostasis networkDOI 10.1101/2024.05.15.594402Read

Spinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular DysfunctionSemantic proximity Read

The SMN Complex at the Crossroad between RNA Metabolism and NeurodegenerationSemantic proximity Read

The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activitySemantic proximity Read

The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP AssemblySemantic proximity Read

A Comprehensive Interaction Map of the Human Survival of Motor Neuron (SMN) ComplexSemantic proximity Read

Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteinsSemantic proximity Read

Spliceosomal small nuclear ribonucleoprotein biogenesis defects and motor neuron selectivity in spinal muscular atrophy.Semantic proximity Read

Essential Role for the Tudor Domain of SMN in Spliceosomal U snRNP Assembly: Implications for Spinal Muscular AtrophySemantic proximity Read

Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Display Altered Proteomes at Early Stages of DifferentiationSemantic proximity Read

U1 snRNP-Specific U1C Acts as the Gatekeeper of the Survival of Motor Neurons (SMN) Complex in snRNP BiogenesisSemantic proximity Read

Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localizationSemantic proximity Read

Emerging Roles of Gemin5: From snRNPs Assembly to Translation ControlSemantic proximity Read