Article

TSProm: Deciphering the Genomic Context of Tissue Specificity

2025-10-31

Abstract excerpt

Characterizing tissue-specific (TSp) gene expression is crucial for understanding development and disease; however, traditional expression-based methods often overlook the latent “regulatory grammar” embedded in the non-coding DNA, particularly in distal promoter regions. Here, we introduce TSProm , a framework that specializes a DNA foundation model (DNABERT2) to decipher the long-range regulatory logic of TSp p...

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Literature Corpus work: 90b5196d-2023-5f6e-b6b3-22235563204e
DOI: 10.1101/2025.10.30.685161

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